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KMID : 0438420080150010017
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Korean Journal of Bone Metabolism
2008 Volume.15 No. 1 p.17 ~ p.24
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Changes of Serum Parathyroid Hormone and Bone Turnover Status According to Serum Vitamin D Levels in Korean Postmenopausal Women
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Park So-Young
Yim Chang-Hoon
Kim Sung-Hoon
Han Ki-Ok
Yoon Hyun-Koo
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Abstract
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Objective: Vitamin D plays a major role in calcium homeostasis and bone turnover. The object of this study is to investigate changes of serum parathyroid hormone and bone turnover status related to serum vitamin D levels in Korean postmenopausal women.
Methods: A retrospective chart review study was conducted among 472 postmenopausal women attending the department of endocrinology between January 2000 and December 2002. We included women without a history of diseases or medications known to affect bone and calcium metabolism who completed extensive laboratory testing including alkaline phosphatase, 24-hr urinary calcium and phosphate, 25-hydroxyvitamin D, PTH and urinary deoxypyridinoline.
Results: The prevalence of vitamin D deficiency (serum 25-OHD ≤ 20 ng/ml) was 73%. On comparing patients with normal and low 25(OH)D, a significant difference was found in PTH, 24-hr urinary calcium and a bone resorption marker. Using exponential decay formula, the PTH concentration approached a theoretical low plateau at 25(OH)D concentration more than 17.16 ng/ml.
Conclusion: Our study shows that vitamin D deficiency is related to the changes of calcium homeostasis indicators and PTH, which might cause increase in the bone resorption marker.
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KEYWORD
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Vitamin D, Parathyroid hormone, Postmenopausal women, Bone turnover marker
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